David Botstein, an American biologist, died on February 27, 2026.
He was director of the Lewis-Sigler Institute for Integrative Genomics at Princeton University from 2003 to 2013 and held the Anthony B. Evnin Professorship of Genomics.
From 2013 to 2023, he was the founding chief science officer of Calico, a biotechnology company focused on the biology of aging. Botstein was known for his work on a genetic linkage map using restriction fragment length polymorphisms.
David Botstein (September 8, 1942 – February 27, 2026) was an American biologist. He was the director of the Lewis-Sigler Institute for Integrative Genomics at Princeton University from 2003 to 2013, and was the Anthony B. Evnin Professor of Genomics. From 2013 to 2023, he was the founding Chief Science Officer of Calico, a biotechnology company with a focus on the biology of aging to devise interventions to enable people to lead longer and healthier lives.